Skip to main content
. 2023 Nov 14;23(2):e14038. doi: 10.1111/acel.14038

FIGURE 3.

FIGURE 3

Calorie restriction reduces a senescence‐associated gene set in human adipose tissue. (a, b) GSEA plots of the SenMayo gene set comparing baseline to 12 months and baseline to 24 months using recently published RNA sequencing data derived from the adipose tissue specimens of eight CALERIE™ participants randomized to CR (Spadaro et al., 2022). (c) Heat map with expression of a subset of the genes included in SenMayo at baseline, 12 months, and 24 months. (d, e) Normalized gene expression of CDKN1A (P21) and CDKN2A (P16) at baseline, 12 months, and 24 months. CR, calorie restriction; GSEA, gene set enrichment analysis.