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. 2023 Aug 10;66(16):11040–11055. doi: 10.1021/acs.jmedchem.3c00221

Figure 1.

Figure 1

(A) The MPro-nirmatrelvir complex. The structure is based on the PDB entry 7TE0.12 The contoured surface of MPro is shown. Four substrate binding pockets in MPro are labeled. (B) The structures of nirmatrelvir, GC376, 11a, and PF-00835231. Chemical positions in nirmatrelvir are labeled.