Table 4.

Ranking of 8 key regulatory genes identified by the in-silico network perturbation analysis on the endothelial sub-network for male-specific DEGs. The scores assigned to each gene represent the total number of downstream genes in the Tg2576-associated regulatory network, whose gene expression can be reverted toward the WT expression pattern through the modulation of the corresponding upstream regulator (sorted from highest score on the left to lowest score on the right)

Gene	Egr1	Klf6	Klf4	Hspb1	Nfkbia	Hes1	Edn1	Son
Score	15	13	12	5	3	3	3	2