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. 2024 Feb 12;12(2):e008189. doi: 10.1136/jitc-2023-008189

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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OS in patients with (A) tumor PD-L1 expression <1% and squamous histology, (B) tumor PD-L1 expression <1% and non-squamous histology, (C) tumor PD-L1 expression ≥1% and squamous histology, and (D) tumor PD-L1 expression ≥1% and non-squamous histology. Subgroups defined on the basis of baseline tumor PD-L1 expression level in the clinical database and histology per interactive response technology. The 95% CIs for 4-year rates for nivolumab (NIVO) plus ipilimumab (IPI) with chemotherapy (chemo) and chemo alone, respectively, were: (A) 12–40 and 1–16; (B) 15–31 and 10–25; (C) 11–28 and 6–21; (D) 15–30 and 12–26. OS, overall survival; PD-L1, programmed death ligand 1.