Table 2.
Main predictive biomarkers for response to anti-VEGF
| GENE | Polymorphism | Anti-VEGF response |
| VEGFA | rs3025000 TT/TC | Positive |
| rs699946 G | Positive | |
| rs833068 GG | Positive | |
| rs3025039 TT | Positive | |
| 2578AA | Negative | |
| VEGFR1 | rs7993418 TC/TT | Positive |
| CFH | rs1061170 CC | Negative |
| rs800292 | Negative | |
| rs1329428 | Negative | |
| rs1410996 | Negative | |
| HRTA1 | LOC387715 T | Positive |
| rs12614 | Positive | |
| APOE | ε4 | Positive |
| SERPINF1 | rs12603486 A | Negative |
| rs1136287 CT/CC | Negative |
anti-VEGF, anti-vascular endothelial growth factor; APOE, apolipoprotein E; CFH, complement factor H; HRTA1, high-temperature requirement factor A1; SERPINF1, serpin family F member 1.