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Mitogenic activity of wild-type and mutant SPECs. Normal human PBL were incubated with each toxin for 56 h and pulsed with 0.5 μCi of [3H]thymidine for 16 h, and [3H]thymidine incorporation was determined. Values are means of triplicate determinations. (A) ○, wild-type SPEC; •, K3E: ▵, D5V; ▴, L14D. (B) ○, wild-type SPEC; •, Y15I; ▵, A16E; ▴, Y17I; □, T20I; ■, D23V; ▿, Y24L. (C) ○, wild-type SPEC; •, N30R; ▵, S32E; ▴, T33R; □, N38I; ■, D40A.
