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Erythematous reaction induced in a rabbit by intradermal injection of SPEC. (A) Erythema that developed 4 h after wild-type SPEC (200 ng) was injected intradermally into an unsensitized rabbit. (B) Histology of an erythematous lesion that developed 4 h after wild-type SPEC (200 ng) was injected intradermally into a rabbit that had received an injection of the same dose of wild-type SPEC 1 week previously. Hematoxylin-and-eosin staining. Bar, 50 μm.
