Table 3.

Published rivaroxaban dosing strategy in Einstein Jr and UNIVERSE clinical trials

Einstein Jr phase 3 (VTE treatment) Body weight–adjusted rivaroxaban regimens in a 20-mg equivalent dose			UNIVERSE phase 3 (post-Fontan thromboprophylaxis) Body weight–adjusted rivaroxaban regimens in a 10-mg equivalent dose (mg or mL∗)
Body weight	Dose	Total	Body weight	Dose	Total
2.6 to <3 kg	0.8 mg per dose TID	2.4 mg	7 to <8 kg	1.1 mg per dose BID	2.2 mg
3 to <4 kg	0.9 mg per dose TID	2.7 mg	8 to <10 kg	1.6 mg per dose BID	3.2 mg
4 to <5 kg	1.4 mg per dose TID	4.2 mg	10 to <12 kg	1.7 mg per dose BID	3.4 mg
5 to <7 kg	1.6 mg per dose TID	4.8 mg	12 to <20 kg	2 mg per dose BID	4.0 mg
7 to <8 kg	1.8 mg per dose TID	5.4 mg	20 to <30 kg	2.5 mg per dose BID	5.0 mg
8 to <9 kg	2.4 mg per dose TID	7.2 mg
9 to <10 kg	2.8 mg per dose TID	8.4 mg
10 to <12 kg	3 mg per dose TID	9 mg
12 to <30 kg	5 mg per dose BID	10 mg
30 to <50 kg	15 mg per dose OD	15 mg
≥50 kg	20 mg per dose OD	20 mg

Reprinted from McCrindle et al¹⁷ (© 2021 by the authors; published on behalf of the American Heart Association, Inc, by Wiley Blackwell), with permission from Wiley Blackwell, and from Male et al¹⁶ with permission from Elsevier.

BID, twice daily; OD, once daily; TID, 3 times daily.

^∗Oral suspension 0.1% (1 mg/mL).