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. Author manuscript; available in PMC: 2024 Feb 13.
Published in final edited form as: Am J Respir Cell Mol Biol. 2004 Jun 10;31(4):382–394. doi: 10.1165/rcmb.2004-0060OC

Figure 8.

Figure 8.

Cytokine induction of secretory genes in Clara cells. Reporter constructs containing the firefly luciferase cDNA under the control of either the mouse Muc5ac, CCSP, or Rab3D promoters were co-transfected into mtCC1–2 cells with the HSV-TK Renilla luciferase control vector. Left. The CCSP and Rab3D promoters, but not the Muc5ac promoter or the promoterless firefly luciferase vector (pGL3 Basic), are constitutively active under resting conditions. * indicates statistically significant difference from Muc5ac and pGL3 Basic transfected cells. Right. Stimulation of mtCC1–2 cells for 24 h with IL-13 (100 ng/ml) or EGF (100 ng/ml) induces Muc5ac promoter activation. * indicates statistically significant difference from unstimulated Muc5ac promoter transfected cells.