Fig. 2.

Modelled trajectories of 10-year patient distribution and flow between health states. All health states are mutually exclusive. The closed cohort model shows the 10-year flow among the incident patients diagnosed in 2023, with the tenth cycle equivalent to the year 2032. The open cohort model shows the annual snapshot of patient distribution between states among the patients diagnosed in the recent 10 years counting from the corresponding calendar year. The pandemic impact was not accounted. Abbreviations: NTRD, Non-treatment-resistant depression; TRD, Treatment-resistant depression.