Fig. 4.

Projected costs and mortality burden by 2032 stratified by subgroups in the closed cohort model. The cumulative burden refers to the projected total collective costs of care or number of deaths accumulated in 10 years in one subgroup. The annualized burden per patient refers to the projected annual individual costs of care or the annual mortality rate, calculated by dividing the cumulative burden (nominator) by the years of lives lived (denominator) accumulated in 10 years in one subgroup. All costs are undiscounted and valued in 2023 U.S. Dollars (USD).