Table 1.
LBRAD treatment clinical trials/case reports in somatization symptoms of depression.
| Study | Subjects | LBRAD administration | Results |
|---|---|---|---|
| Zhao., 2017 [26] | 68 patients with depression and anxiety | Group 1: Treated with Delexin, take 1 tablet once a day in the morning and noon for 8 weeks. Group 2: LBRAD(30 g lily bulbs; 10 g Anemarrhena) and Ganmai Dazao decoction were taken once a day in 2 divided doses for 8 weeks. |
The total effective rate of treatment: Group 2(97.06 %) was higher than Group 1(73.53 %); Group 2 vs Group 1(X2 = 7.503, P = 0.006); Overall scores of HAMD after the intervention: Group 2 was lower than Group 1; Group 2 vs Group 1(P < 0.05); The incidence of adverse reactions between the two groups during treatment(X2 = 7.503, P = 0.006), The incidence of adverse reactions in Group 2 was lower than that in Group 1. |
| Feng et al., 2020 [27] | 105 patients with depression and anxiety | Group 1: Fluoxetine hydrochloride capsules (produced by Eli Lilly Suzhou Pharmaceutical Co., Ltd., national drug approval number J20170022), taken orally in the morning, 1 capsule/d, for a total of 8 weeks of treatment. Group 2: The same administration method as group 1; LBRAD(30 g lily bulbs; 10 g Anemarrhena) and Ganmai Dazao decoction were taken once a day in 2 divided doses for 8 weeks, and psychotherapy. |
The total effective rate of treatment: Group 2(92.73 %) was higher than Group 1(74.00 %); Group 2 vs Group 1(P < 0.05); Overall scores of QOL-BREF after the intervention: Group 2 was higher than Group 1; Group 2 vs Group 1(P < 0.05); Overall scores of HAMD after the intervention: Group 2 was lower than Group 1; Group 2 vs Group 1(P < 0.05); The incidence of adverse reactions between the two groups during treatment(X2 = 8.376, P < 0.05), The incidence of adverse reactions in Group 2 was lower than that in Group 1. |
| Zhu and Zhang., 2000 [28] | 46 patients with depression and sleep disorders | LBRAD(50 g lily bulbs; 15 g Anemarrhena) addition and subtraction, prepared 500 ml, taken 200 ml after dinner, and taken another 300 ml before going to bed every night, for 10 consecutive days of treatment. | 24 cases were cured, 18 cases were effective, and 4 cases were ineffective. The total effective rate was 91.30 %. |
| Fang., 2012 [29] | 52 patients with depression and sleep disorders | LBRAD(30 g lily bulbs; 10 g Anemarrhena) addition and subtraction, was taken once a day in 2 divided doses for 10 consecutive days. | 45 cases were cured, 6 cases were markedly effective, and 1 case was ineffective. The total effective rate was 98.08 %. |
| Liu., 2018 [30] | 130 patients with depression and irritability | Group 1: Oral estazolam tablets (Beijing Shuanghe Pharmaceutical Co., Ltd., national drug approval number: H11020744), 1–2 mg each time, once a day, for 1 month. Group 2: LBRAD(30 g lily bulbs; 10 g Anemarrhena) addition and subtraction, was taken once a day in 2 divided doses for 1 month. |
The total effective rate of treatment: Group 2(90.77 %) was higher than Group 1(56.92 %); Group 2 vs Group 1(X2 = 19.277, P < 0.05); Overall scores of SAS, SDS, and PSQI after the intervention: Group 2 was lower than Group 1; Group 2 vs Group 1(P < 0.05). |
| Chen and Ding., 2012 [31] | 80 patients with depression and irritability | Group 1: Oral fluoxetine hydrochloride capsules (produced by Eli Lilly and Company of the United States, national drug approval number J20080016, capsule, 20 mg/capsule), 20 mg per day, taken with a meal in the morning, for 8 weeks. Group 2: LBRAD(30 g lily bulbs; 15 g Anemarrhena) and Longgu Muli decoction were taken once a day in 2 divided doses for 8 weeks. |
The total effective rate of treatment: Group 2(92.5 %) was higher than Group 1(87.5 %); Group 2 vs Group 1(P < 0.05); |
| Gao and Liu., 2006 [33] | 1 patient with depression and breast hyperplasia | LBRAD(30 g lily bulbs; 12 g Anemarrhena) addition and subtraction, was taken once a day in 2 divided doses for 3 consecutive months. | Overall treatment rate 100 % |
| Zhang et al., 2021 [34] | Case 1: 1 patient with depression and chronic prostatitis; Case 2: 1 patient with depression and impotence | Case 1: LBRAD(20 g lily bulbs; 10 g Anemarrhena) addition and subtraction, was taken once a day in 2 divided doses for 5 consecutive weeks. Case 2: LBRAD(20 g lily bulbs; 15 g Anemarrhena) addition and subtraction, was taken once a day in 2 divided doses for 5 consecutive weeks. |
Case 1: The SDS score was significantly lower than before treatment. Overall treatment rate 100 % Case 2: Overall treatment rate 100 % |