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[Preprint]. 2024 Jan 31:2024.01.29.577497. [Version 1] doi: 10.1101/2024.01.29.577497

Fig. 1. Prymnesin, its source PKZILLA polyketide synthases (PKSs), and other large proteins and PKS systems.

Fig. 1.

(A) Molecular structure of prymnesin-1 (16). (B) Comparison of polypeptide and coding nucleotide sizes from representative PKSs or computationally summed PKS systems. Blue=PKZILLAs from P. parvum 12B1 (this work). [S]=Computationally summed lengths for independent PKS proteins that participate in the same biosynthetic system. Black dashed lines=Divisions of PKS systems into independent proteins. Red/*=largest known protein (non-PKS) (15). Gold=Representative bacterial PKS systems, including the quinolidomicin (**=previous largest known PKS system) (17) and erythromycin (18) PKSs. Green/***=previous largest genetically studied microalgal PKS (13).