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[Preprint]. 2024 Feb 1:2024.02.01.578466. [Version 1] doi: 10.1101/2024.02.01.578466

Figure 1. Replication kinetics and morphologic analysis of RSV infected pediatric HNO-ALIs and adult HNO-ALIs.

Figure 1.

A) Apical RT PCR for 4 adult and 4 pediatric HNO-ALIs for RSV/A/ON and RSV/B/BA and B) corresponding plaque data. C) Apical RT PCR for 4 adult and 4 pediatric HNO-ALIs for RSV/B/BA and D) corresponding plaque data. E) PFU data was modeled using the covariates: HNO age interacting with dpi, and viral infection. Forest plot demonstrating the adjusted beta coefficient estimate with 95% confidence intervals, represented by dots and T bars, respectively, between adult and pediatric HNO-ALIs. F) H&E images of adult HNO-ALI 918 at 5 and 8 day post-infection (dpi). (* denotes goblet cells). G) H&E images of pediatric HNO-ALI 9003 at 5 and 8 dpi. (* denotes goblet cells). H) Comparison of epithelial area between pediatric and adult HNO-ALIs at 5 and 8 dpi with RSV/A/ON, RSV/B/BA, or mock infection. Scale bar is 100 μm.