Table 1.

Values of tau for dephosphorylation of pCaMKII in the non-trapping and trapping cases were determined at different simulated concentrations of PP1 from the data shown in Figures 9 and 10, respectively, as described under Methods. The values of tau in the presence of competition for binding between CaM and PP1 were determined for the non-trapping case from the data shown in Fig. 12 B, and for the trapping case from Fig. 13. The tau for Epoch 1 was identical to that of Epoch 2 as determined by measuring the decay of pCaMKII from the peak at 4 secs to 5 secs, which was identical to that of Epoch 2 from the peak at 7.7 secs to 8.7 secs. Tau’s for CaM4, CaM2C, and CaM2C1N from Fig. 13B were 61.7, 57.2, and 59.2, respectively.

[PP1]	Tau Non-trapping		Tau Trapping		Tau Non-trapping CaM vs. PP1 competition		Tau Trapping CaM vs. PP1 competition
	Epoch 1	Epoch 2	Epoch 1	Epoch 2	Epoch 1	Epoch 2	Epoch 1	Epoch 2
0.65 μM	5.0 s	4.9 s	5.01 s	4.8 s
1.25 μM	1.9 s	1.7 s	2.0 s	1.8 s	2.3 s	1.9 s	60.4 s	60.4 s
2.5 μM	0.74 s	0.65 s	0.74 s	0.67 s
5.0 μM	0.33 s	0.32 s	0.38 s	0.32 s