Table 2.
Polymorphism which increased in frequency between 2016/2017 and 2020/2021
| Gene | Chr:Position | Number of NSY in 99th percentile | Description | Codons | AA |
|---|---|---|---|---|---|
| PF3D7_0113800 | 1:527107–536351 | 3 | DBL containing protein, unknown function | 3436G>A; 3445C>T; 8458G>A | Glu1146Lys; His1149Tyr; Val2820Ile |
| PF3D7_0216800 | 2:696193–699561 | 3 | TMEM121 domain-containing protein, putative | 1381T>A; 1373G>A; 938A>G | Cys461Ser; Ser458Asn; Gln313Arg |
| PF3D7_0418600 | 4:834394–840429 | 3 | regulator of chromosome condensation, putative | 2254T>G; 2255G>T; 2270C>T | Gly748Asp; Cys752Gly; Cys752Phe |
| PF3D7_0609000 | 6:370261–388494 | 1 | nucleoporin NUP637, putative | 12682G>C | Glu4228Gln |
| PF3D7_0609700 | 6:413652–419781 | 1 | protein KIC6 | 5038C>A | Gln1680Lys |
| PF3D7_0701900 | 7:79890–82943 | 4 | Plasmodium exported protein, unknown function | 2654T>A; 2091T>A; 2075G>A; 2013T>A | Ile885Lys; Asp697Glu; Ser692Asn; Asn671Lys |
| PF3D7_0704000 | 7:167489–177295 | 1 | conserved Plasmodium membrane protein, unknown function | 2220A>C | Glu740Asp |
| PF3D7_0723800 | 7:993232–1000233 | 1 | apicomplexan kinetochore protein 1, putative | 2129A>T | Glu710Val |
| PF3D7_0828200 | 8:1216271–1220716 | 1 | leucine--tRNA ligase, putative | 3201A>T | Lys1067Asn |
| PF3D7_0831600 | 8:1358314–1363618 | 1 | cytoadherence linked asexual protein 8 | 4099A>G | Lys1367Glu |
| PF3D7_0902400 | 9:106514–108406 | 1 | serine/threonine protein kinase, FIKK family | 58T>C | Tyr20His |
| PF3D7_0902500 | 9:109334–111329 | 1 | serine/threonine protein kinase, FIKK family | 865T>C | Cys289Arg |
| PF3D7_0903300 | 9:140977–150588 | 2 | conserved Plasmodium membrane protein, unknown function | 2518A>T; 4167A>T | Ile840Phe; Lys1389Asn |
| PF3D7_0904200 | 9:197867–198816 | 1 | PH domain-containing protein, putative | 465C>A | Asn155Lys |
| PF3D7_0904300 | 9:199051–207458 | 1 | conserved protein, unknown function | 3445T>A | Tyr1149Asn |
| PF3D7_0904600 | 9:212515–217983 | 1 | ubiquitin specific protease, putative | 2032A>G | Ile678Val |
| PF3D7_0905300 | 9:251353–269709 | 1 | dynein heavy chain, putative | 2182A>T | Asn728Tyr |
| PF3D7_0905500 | 9:278369–279088 | 1 | conserved Plasmodium protein, unknown function | 65C>G | Ala22Gly |
| PF3D7_1001600 | 10:86538–89009 | 1 | alpha/beta hydrolase, putative | 1676C>T | Ala559Val |
| PF3D7_1004400 | 10:207000–209642 | 2 | RNA-binding protein, putative | 776C>G; 575A>G | Ala259Gly; Asn192Ser |
| PF3D7_1005300 | 10:233285–234473 | 2 | conserved Plasmodium protein, unknown function | 759A>T; 11A>T | Glu253Asp; Asn4Ile |
| PF3D7_1005400 | 10:234795–235745 | 1 | conserved Plasmodium protein, unknown function | 225T>A | Asn75Lys |
| PF3D7_1107300 | 11:301283–311287 | 1 | polyadenylate-binding protein-interacting protein 1, putative | 9430A>T | Ile3144Phe |
| PF3D7_1129300 | 11:1131294–1136834 | 1 | conserved Plasmodium protein, unknown function | 1477G>A | Gly493Arg |
| PF3D7_1138400 | 11:1501011–1513691 | 1 | guanylyl cyclase | 11060A>G | Tyr3687Cys |
| PF3D7_1139100 | 11:1548186–1553561 | 1 | RNA-binding protein, putative | 4289G>A | Arg1430Lys |
| PF3D7_1139300 | 11:1556744–1565045 | 3 | transcription factor with AP2 domain(s) | 7404A>C; 5701G>A; 1577C>G | Gln2468His; Gly1901Ser; Thr526Ser |
| PF3D7_1342200 | 13:1660812–1663730 | 1 | conserved Plasmodium membrane protein, unknown function | 2902G>A | Asp968Asn |
| PF3D7_1343700 | 13:1724817–1726997 | 1 | kelch protein K13 | 566A>C | Lys189Thr |
| PF3D7_1344000 | 13:1759466–1761991 | 1 | aminomethyltransferase, putative | 922A>G | Lys308Glu |
| PF3D7_1344100 | 13:1764190–1766607 | 1 | krox-like protein, putative | 2170C>G | Gln724Glu |
| PF3D7_1346400 | 13:1852898–1870864 | 1 | VPS13 domain-containing protein, putative | 9661C>A | His3221Asn |
| PF3D7_1346700 | 13:1876016–1877362 | 2 | 6-cysteine protein | 1307C>T; 940T>A | Thr436Ile; Leu314Ile |
| PF3D7_1346800 | 13:1878875–1880194 | 2 | 6-cysteine protein | 532A>G; 203C>T | Ile178Val; Thr68Met |
| PF3D7_1360800 | 13:2435343–2438924 | 1 | falcilysin | 28A>T | Ile10Phe |
| PF3D7_1417700 | 14:750330–751684 | 1 | conserved Plasmodium protein, unknown function | 364G>T | Asp122Tyr |
| PF3D7_1418900 | 14:783078–785819 | 1 | ATP-dependent RNA helicase DBP4, putative | 2135T>C | Val712Ala |
| PF3D7_1419400 | 14:804425–811369 | 3 | conserved Plasmodium membrane protein, unknown function | 5150G>T; 2898T>A; 2605G>A | Gly1717Val; Asn966Lys; Asp869Asn |
| PF3D7_1453600 | 14:2199371–2204708 | 2 | RAP protein, putative | 3689A>T; 3669T>G | Lys1230Ile; Asn1223Lys |
| PF3D7_1474200 | 14:3023852–3038832 | 1 | conserved Plasmodium membrane protein, unknown function | 9554C>T | Ser3185Leu |
| PF3D7_1478100 | 14:3216275–3217794 | 1 | Plasmodium exported protein (hyp13), unknown function | 721A>G | Ile241Val |