Table 2.
Disability weights for health economic evaluations where the primary outcome was measured in DALYs
| Study | Neonatal | Adult | ||||
|---|---|---|---|---|---|---|
| Health state | Disability weight | Duration | Health state | Disability weight | Duration | |
| Bristow (2016) [21] | Congenital syphilis | 0·315 | 3 years | ·· | ·· | ·· |
| Low birth weight or prematurity | 0·106 | 1 year | ·· | ·· | ·· | |
| Miscarriage | 0 | ·· | ·· | ·· | ·· | |
| Stillbirth | 0 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Hong (2010) [22] | Congenital syphilis | 0·315 | 3 years | ·· | ·· | ·· |
| Fetal and neonatal death (including neonatal death due to low birth weight, neonatal death due to congenital syphilis, perinatal death, spontaneous abortion, medical/induced abortion) | 1 | ·· | ·· | ·· | ·· | |
| Jayawardena (2019) [23] | ·· | ·· | ·· | Mild early syphilis (primary or secondary) | 0·006 (0·002-0·012) | 0·07 years |
| ·· | ·· | ·· | Tertiary syphilis | 0·203 (0·134-0·29) | 10 years | |
| Congenital syphilis | 0·315 | 3 years | ·· | ·· | ·· | |
| Kahn (2014) [24] | Congenital syphilis | 0·316 | Lifetime | ·· | ·· | ·· |
| Low birth weight | 0·106 | Lifetime | ·· | ·· | ·· | |
| Stillbirth | Calculated as a set number of DALYs per stillbirth – 4·95 DALYs | ·· | ·· | ·· | ·· | |
| Neonatal death | Calculated as a set number of DALYs per neonatal death – 9·4 DALYs | |||||
| Kuznik (2013) [25] | Congenital syphilis | 0·315 (0·159-0·471) | Lifetime | ·· | ·· | ·· |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Kuznik (2015) [26] | Congenital syphilis | 0·315 (0·159-0·471) | Not specified | ·· | ·· | ·· |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Larson (2014) [27] | Congenital syphilis | 0·316 | Lifetime | ·· | ·· | ·· |
| Low birth weight | 0·106 | Lifetime | ·· | ·· | ·· | |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Owusu-Edusei (2011) [28] | ·· | ·· | ·· | Early syphilis (primary or secondary) | 0·032 (0·015-0·048) | Not specified |
| ·· | ·· | ·· | Tertiary syphilis | 0·283 (0·250-0·300) | Not specified | |
| Congenital syphilis | 0·315 (0·250-0·350) | 3 years | ·· | ·· | ·· | |
| Low birth weight | 0·106 (0·090-0·130) | 1 year | ·· | ·· | ·· | |
| Miscarriage | 1 | ·· | ·· | ·· | ·· | |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Owusu-Edusei (2014) [29] | ·· | ·· | ·· | Early (primary or secondary) syphilis | 0·015 (0·0075-0·0225) | Not specified |
| ·· | ·· | ·· | Tertiary syphilis | 0·283 (0·01415-0·4245) | Not specified | |
| ·· | ·· | ·· | HIV-positive pregnant women with syphilis coinfection | 0·38 | Not specified | |
| Congenital syphilis | 0·315 (0·1575-0·47) | 3 years | ·· | ·· | ·· | |
| Low birth weight | 0·106 (0·053-0·159) | 1 year | ·· | ·· | ·· | |
| Induced abortion | 0 | ·· | ·· | ·· | ·· | |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Rodriguez (2021) [30] | Congenital syphilis | 0·315 | 3 years | ·· | ·· | ·· |
| Low birth weight | 0·106 | 1 year | ·· | ·· | ·· | |
| Stillbirth | 1 | First 20 years of life | ·· | ·· | ·· | |
| Neonatal death | 1 | First 20 years of life | ·· | ·· | ·· | |
| Romero (2020) [31]a | Congenital syphilis | 0·315 | Lifetime | ·· | ·· | ·· |
| Low birth weight | 0·106 | Lifetime | ·· | ·· | ·· | |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Russell (2021) [41] | ·· | ·· | ·· | Syphilis | 0·12 (0·09-0·15) | 90 days |
| Schackman (2007) [32] | Congenital syphilis | 0·315 (0·1575-0·4725) | Lifetime | ·· | ·· | ·· |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
| Terris-Prestholt (2003) [33] | Low birth weight | 0·291 | Lifetime | ·· | ·· | ·· |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Terris-Prestholt (2015) [34] | Congenital syphilis | 0·315 | Lifetime | ·· | ·· | ·· |
| Low birth weight | 0·291 | Lifetime | ·· | ·· | ·· | |
| Stillbirth | 1 | ·· | ·· | ·· | ·· | |
| Neonatal death | 1 | ·· | ·· | ·· | ·· | |
Ranges or confidence intervals used for sensitivity analyses are placed in brackets
DALY Disability-adjusted life year, HIV Human immunodeficiency virus
aWeights not explicitly stated in the study but are taken from a paper referenced in the bibliography [25]