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Schematic diagram of the mechanisms involved in extra- and intracellular trafficking by which PrPC may affect GBM biology. PrPC is transiently found in the ER and Golgi during its biogenesis and is internalized by a vesicle-mediated process to be recycled or degraded. Vesicular biogenesis, endocytic path and exocytosis are processes enriched in GBM cells with high PRNP expression
