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. 2024 Feb 12;24:72. doi: 10.1186/s12935-024-03253-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Filamin-B and Periostin transcripts are enriched in EVs isolated after irradiation. A. GSEA of highly modulated genes as assessed by RNA-Seq on EVs derived from irradiated GSC#61 (50 Gy) compared to EVs derived from sham-irradiated GSC#61 (upper panel). qRT-PCR analysis of CENPJ, CNTROB, FLNB and LMNB expression in GSC-derived EVs isolated from sham irradiated (EVs) and irradiated (EVs 50 Gy) GSC#61 (lower panel). Samples were run in duplicate. Data were normalized to the GAPDH expression in the corresponding samples. B. GSEA of highly modulated genes as assessed by RNA-Seq on EVs derived from irradiated HMVECs (50 Gy) compared to EVs derived from sham-irradiated HMVECs (upper panel). qRT-PCR analysis of GEM, MCM7, PMEPA1 and POSTN expression in HMVEC-derived EVs isolated from sham irradiated (EVs) and irradiated cells (EVs 50 Gy). Samples were run in duplicate. Data were normalized to the GAPDH expression in the corresponding samples