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. 2024 Feb 13;22:148. doi: 10.1186/s12967-024-04913-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — | SAE1 is overexpressed in gastric cancer (GC) and is associated with poor prognosis in GC patients. A The transcription levels of SAE1 in different tumor types from TCGA data analyzed in TIMER database. B Normalized expression value of SAE1 (log 2 transformation and Z correction) in GC tissues and adjacent tissues from the TCGA database. C The graph summarized immunohistochemical (IHC) scores of SAE1 expression in 93 pairs of GC and adjacent tissues from tissue microarray. D Representative images of IHC staining for SAE1 in human GC tissue microarray with 93 tumor tissues and paired adjacent tissues. (Magnification 40 × , 100 × , and 200 × ; bars = 20 μm). E The survival plot shows the prognosis in 304 GC patients with high SAE1 expression and 327 gastric cancer patients with low SAE1 expression from Kaplan–Meier Plotter database. F The survival plot shows the prognosis in 65 gastric cancer patients with high SAE1 expression and 28 gastric cancer patients with low SAE1 expression from GC tissue microarray. G SAE1 expression in several GC cell lines was analyses by western blot. The data is representative of 3 independent experiments