Table 3.
Univariate analysis by prognostic factors for recurrence-free survival
| Prognostic factors | Overall Cohort | EGFRm Cohort | PD-L1 positive Cohort | |||
|---|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |
| Smoking | ||||||
| Never | Ref | Ref | Ref | |||
| Current or former | 1.55 (1.03–2.34) | 0.033 | 2.12 (1.15–3.89) | 0.015 | 0.44 (0.15–1.22) | 0.117 |
| COPD | ||||||
| No | Ref | Ref | Ref | |||
| Yes | 1.72 (0.98–3.01) | 0.054 | 1.39 (0.43–0.46) | 0.572 | 0.51 (0.11–2.23) | 0.375 |
| CEA | ||||||
| < 3.8 ng/ml | Ref | Ref | Ref | |||
| ≥ 3.8 ng/ml | 2.57 (1.57–4.19) | < 0.001 | 4.84 (2.23–10.46) | < 0.001 | 1.75 (0.55–5.56) | 0.339 |
| pT | ||||||
| pT1 | Ref | Ref | Ref | |||
| pT2a | 2.02 (1.27–3.20) | 0.003 | 1.91 (1.05–3.46) | 0.031 | 2.44 (0.82–7.29) | 0.108 |
| pT2b | 3.73 (2.03–6.85) | < 0.001 | 3.80 (1.62–8.97) | 0.002 | 0.94 (0.11–7.92) | 0.961 |
| pT3 | 3.81 (2.30–6.30) | < 0.001 | 2.22 (0.95–5.19) | 0.064 | 3.90 (1.09–13.94) | 0.036 |
| pT4 | 4.98 (2.42–10.24) | < 0.001 | 4.73 (1.41–15.83) | 0.012 | 2.16 (0.25–18.29) | 0.477 |
| pN | ||||||
| pN0 | Ref | Ref | Ref | |||
| pN1 | 3.88 (2.33–6.44) | < 0.001 | 2.93 (1.48–5.78) | 0.002 | 2.01 (0.40–10.07) | 0.395 |
| pN2 | 4.31 (2.18–8.53) | < 0.001 | 5.69 (3.08–10.51) | < 0.001 | 7.43 (2.72–20.31) | < 0.001 |
| pStage | ||||||
| I | Ref | Ref | Ref | |||
| II | 3.30 (2.12–5.13) | < 0.001 | 2.15 (1.11–4.17) | 0.022 | 7.16 (1.37–37.24) | 0.019 |
| III | 6.74 (4.40–10.33) | < 0.001 | 6.53 (3.65–11.69) | < 0.001 | 14.27 (3.18–64.02) | 0.001 |
| Margin | ||||||
| Negative | Ref | Ref | Ref | |||
| Positive | 4.31 (2.18–8.53) | < 0.001 | 3.81 (1.52–9.59) | 0.004 | 1.44 (0.18–11.02) | 0.724 |
| LVI | ||||||
| Negative | Ref | Ref | Ref | |||
| Positive | 3.28 (2.27–4.74) | < 0.001 | 3.22 (1.90–5.43) | < 0.001 | 5.96 (1.73–20.51) | 0.005 |
| Pleural invasion | ||||||
| Negative | Ref | Ref | Ref | |||
| Positive | 2.35 (1.61–3.42) | < 0.001 | 2.18 (1.28–3.71) | 0.004 | 1.58 (0.59–4.18) | 0.354 |
| Histology | ||||||
| Lepidic | Ref | Ref | Ref | |||
| Acinar | 2.59 (1.46–4.60) | 0.001 | 3.54 (1.49–8.42) | 0.004 | 0.91 (0.19–4.32) | 0.908 |
| Micropapillary | 5.41 (2.29–12.78) | < 0.001 | 4.33 (0.87–21.54) | 0.073 | 1.25 (0.23–6.72) | 0.789 |
| Papillary | 4.15 (2.02–8.50) | < 0.001 | 4.58 (1.62–12.94) | 0.004 | 1 | |
| Solid | 4.86 (2.27–10.40) | < 0.001 | 10.66 (2.97–38.22) | < 0.001 | 0.45 (0.072–2.85) | 0.401 |
| Mucinous | 2.83 (1.27–6.30) | < 0.001 | 6.69 (1.33–33.49) | 0.021 | 0.73 (0.06–8.10) | 0.801 |
| EGFR status | ||||||
| Wild-type | Ref | - | - | |||
| Mutated | 0.88 (0.60–1.28) | 0.518 | - | - | ||
| PDL1 SP263 | ||||||
| Negative | Ref | - | - | |||
| ≥ 1 | 1.75 (1.03–2.98) | 0.036 | - | - | ||
HR Hazard ratio, Ref Reference