Table 3.

Gene transcripts normalized by DMF in CUS-exposed female rats (absolute ΔLogFC > 0.3)

GENE	CUS RESPONSE	Encoded protein function
Tpt1	↑	Translationally-controlled tumor protein 1; Diverse functions including DNA damage repair, autophagy, protein degradation; antioxidant properties and implicated in immune responses
Cnppd1	↑	Cyclin Pas1/PHO80 domain containing 1; function in brain unknown; predicted to be involved in the regulation of cyclin dependent kinase activity
Grm2	↑	Metabotropic glutamate receptor 2; activation is anti-inflammatory; implicated in depression, stress resilience and vulnerability, anxiety
Zfp46	↓	Zinc finger protein 46, transcription factor; biological functional pathways unknown
Olr522	↓	Encodes for an olfactory receptor; specific function unknown although several functions for non-chemosensory regions in brain have been characterized
Dcn	↓	Decorin; extracellular matrix proteoglycan; plays a key role in inflammatory and autoimmune disorders