Table 4. Predicted and Experimental hERG Activity Data^a.

^aThe experiment response of hERG currents to various compounds at various concentrations were measured through whole-cell voltage clamp experiments. The results of each compound were fitted to Hill equation to obtain the IC₅₀ and Hill coefficient values. IC₅₀ values and Hill coefficients were determined from at least three independent experiments performed in triplicate and are reported as mean ± SEM (μM). The predictions were made using the hERG QSAR models trained with the ChEMBL 31 data set.