Fig. 3.
Metabolome-Wide Association Study (MWAS) of T3DB-annotated chemicals higher in third trimester (T3) serum. Association of seven T3DB-annotated chemicals (Table 4) that are higher in breast cancer than non-cases with the metabolome (9,042 metabolic features) from T3 serum (n = 351 for non-cases, n = 172 for breast cancer) are examined using xMWAS. The network is visualized at |r| ≥ 0.3 and includes two communities (C4 and C5) showing central four chemicals with tight connections [C4 (orange)] than C5 (blue)]. Representative metabolites of pathways associated with community are shown next to each community.