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A schematic diagram of how local (nanometer domain) sodium gradients influence osmotic sensors, effectors, and immune cells. eNOS indicates endothelial NO synthase; TonEBP, tonicity-responsive enhancer-binding protein; VEGF-C, vascular endothelial growth factor; VEGFR-2, vascular endothelial growth factor receptor-2; and VEGFR-3, vascular endothelial growth factor receptor-3.
