TABLE 1.
Baseline characteristics of the study sample stratified by age subgroups
| Study sample (n = 8000) | Age 65–74 (n = 5335) | Age 75+ (n = 2665) | P | |
| Age (years), mean ± SD | 72.3 ± 5.6 | 69.5 ± 2.7 | 79.4 ± 3.9 | – |
| Female, n (%) | 3575 (44.7) | 2822 (52.9) | 1603 (60.2) | <0.001 |
| Uric acid (mg/dl), mean ± SD | 5.3 ± 1.4 | 5.2 ± 1.4 | 5.4 ± 1.5 | <0.001 |
| Hypertension (n = 6612), n (%) | 3366 (50.9) | 2134 (48.2) | 1232 (56.3) | <0.001 |
| Diabetes, n (%) | 1435 (17.9) | 876 (16.5) | 559 (21.0) | <0.001 |
| Smoking, n (%) | 1310 (16.4) | 990 (18.6) | 320 (12.0) | <0.001 |
| Chronic kidney disease, n (%) | 1862 (23.3) | 1168 (22.0) | 694 (26.1) | <0.001 |
| Gout (n = 6429), n (%) | 93 (1.4) | 52 (1.2) | 41 (1.8) | 0.068 |
| Allopurinol (n = 6338), n (%) | 129 (2.0) | 69 (1.7) | 60 (2.7) | 0.005 |
| Heart failure (n = 7408), n (%) | 2196 (29.6) | 1235 (25.6) | 961 (37.3) | <0.001 |
| Creatinine (mg/dl), mean ± SD | 0.96 ± 0.3 | 0.94 ± 0.28 | 0.99 ± 0.34 | <0.001 |
| BMI (kg/m2), mean ± SD | 27.1 ± 4.3 | 27.3 ± 4.3 | 26.7 ± 4.3 | <0.001 |
| SBP (mmHg), mean ± SD (n = 7778) | 154.6 ± 24.1 | 153.5 ± 23.7 | 156.8 ± 24.8 | <0.001 |
| DBP (mmHg), mean ± SD (n = 7778) | 85.4 ± 12.6 | 86.4 ± 12.4 | 83.5 ± 12.7 | <0.001 |
| Diuretic therapy, n (%) | 1484 (18.6) | 951 (18.9) | 533 (20.2) | 0.175 |
| Hydrochlorothiazide (n = 2328), n (%) | 345 (14.8) | 196 (14.0) | 149 (16.1) | 0.161 |
| Loop diuretics (n = 5601), n (%) | 425 (7.6) | 203 (5.9) | 222 (10.2) | <0.001 |
BMI, body mass index; CV, cardiovascular; DBP, diastolic blood pressure; IQR, interquartile range; SBP, systolic blood pressure; SD, standard deviation.