TABLE 3.

Age-stratified multivariate Cox analysis for cardiovascular mortality using serum uric acid as a continuous independent variable

	HR	95% CI (lower bound)	95% CI (upper bound)	P
Age 65–74 years
Uric acid (mg/dl)a	1.236	1.171	1.305	<0.001
Uric acid (mg/dl)	1.146	1.064	1.235	<0.001
Male sex	1.857	1.497	2.305	<0.001
Hypertension	1.269	1.016	1.584	0.035
Alcohol use	2.419	1.679	3.484	<0.001
Creatinine (mg/dl)	1.303	1.029	1.649	0.028
Total cholesterol (mg/dl)	1.000	0.998	1.003	0.802
Diuretic use	0.950	0.701	1.288	0.740
Diabetes	1.982	1.567	2.506	<0.001
Chronic kidney disease	1.318	1.034	1.680	0.026
Heart failure	2.461	1.973	3.069	<0.001
Age 75+ years
Uric acid (mg/dl)a	1.074	1.022	1.129	0.005
Uric acid (mg/dl)	1.008	0.941	1.080	0.823
Male sex	1.291	1.046	1.594	0.017
Hypertension	1.375	1.130	1.673	0.001
Alcohol use	2.347	1.703	3.236	<0.001
Creatinine (mg/dl)	0.740	0.484	1.130	0.163
Total cholesterol (mg/dl)	0.998	0.995	1.000	0.062
Diuretic use	0.607	0.458	0.805	0.001
Diabetes	1.770	1.417	2.212	<0.001
Chronic kidney disease	1.152	0.890	1.492	0.282
Heart failure	2.158	1.740	2.675	<0.001

^aUnadjusted.