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. 2024 Feb 13;132(2):027006. doi: 10.1289/EHP13215

Figure 5.

Figure 5 is a flowchart with three steps. Step 1: Did the extracted effect receive a U M L S term via automation? If yes, then Did extracted endpoint receive BfR DevTox and O E C D terms? If no, then Manually map to UMLS. Step 2: Did extracted endpoint receive BfR DevTox and O E C D terms? If yes, then Terms from 3 controlled vocabularies applied to all rows where possible, Apply Crosswalk, and Manually Map BfR DevTox or O E C D terms. If no, then Are the terms Crosswalk Compatible? Step 3: Are the terms Crosswalk Compatible? If yes, Apply Crosswalk. If no, then Manually Map BfR DevTox or O E C D terms.

Manual mapping workflow of extracted end points not standardized to controlled vocabulary terms by the automated annotation code. Crosswalk compatible is defined as all three conditions being met: a) did not receive a Unified Medical Language System (UMLS) term from code, b) has only one UMLS term applied, and c) applied UMLS term crosswalks to no more than one German Federal Institute for Risk Assessment (BfR) DevTox and one Organization for Economic Cooperation and Development (OECD) term.