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. 2023 Dec 29;13(1):e031219. doi: 10.1161/JAHA.123.031219

Figure 3. Deferasirox (DFX) prevents ferroptosis caused by hypoxia/reoxygenation (H/R) in cultured cardiomyocytes.

Figure 3

A, Representative images of cardiomyocytes subjected to H/R, treated with vehicle or 1–200 μM DFX. B, Cell viability of cultured cardiomyocytes subjected to H/R, treated with vehicle or 1 to 200 μM DFX (n=6, each group). Ferrostatin‐1 (Fer‐1) represents the ferroptosis inhibition positive control. Statistical significance was determined using 1‐way ANOVA with Tukey post hoc test. ***P<0.001. Hx indicates hypoxia; Nx, normoxia; and Veh, vehicle.