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. 2023 Dec 29;13(1):e031219. doi: 10.1161/JAHA.123.031219

Figure 7. Combination therapy with deferasirox (DFX) and cyclosporin A (CsA) synergistically reduces infarct size in a murine ischemia reperfusion (I/R) model.

Figure 7

A, Representative images showing double staining with TTC and Evans Blue in I/R mice treated with vehicle control (Veh), DFX, CsA, or DFX+CsA. Scale bar: 1 mm. B, AAR per LV, IFA per LV, and IFA per AAR percentages in I/R mice. AAR indicates area at risk; IFA, infarct area; and LV, left ventricle. I/R Veh, n=6; I/R DFX, n=11; I/R CsA, n=12; I/R DFX+CsA, n=20. Data are presented as the mean±SEM. Statistical significance was determined using 1‐way ANOVA with Tukey post‐hoc test. *P<0.05, **P<0.01, ***P<0.001.