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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Nat Immunol. 2023 Oct 23;24(12):2150–2163. doi: 10.1038/s41590-023-01654-3

Fig. 6: Immune hallmarks of early SD progression.

Fig. 6:

Schematic representation depicting the differences in cell type abundance, phenotype, and immunological function of distinct cell subtypes in SDp (red) vs. uncomplicated D/DWS (blue), and specific attributes of virus-harboring cells (VHCs) (yellow). We propose that ineffective memory responses, accompanied by defective antigen presentation and inflammation resolution mechanisms, in part mediated by active DENV replication in B cells and myeloid cells in human blood, prevail in SDp, whereas adequate presentation of antigens and effective antigen-specific responses characterize D/DWS patients.