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. 2024 Jan 24;11:1322201. doi: 10.3389/fnut.2024.1322201

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Copyright © 2024 Kadyan, Park, Hochuli, Miller, Wang and Nagpal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interplay of gut microbiome and metabolome in regulating cognitive functions, neuroinflammation, endocrinolgical, and hepatic health markers. (A) Heatmaps showing correlational relationships between neurocognitive features (behavior test), serum markers (ELISA measurements), and blood lipid profiles (Piccolo measurements) with respective gut bacterial genera and metabolites. (B) Circos plots depicting relationships between gut microbiome genera and microbial metabolites with host genes in the hypothalamus and frontal cortex. Negative correlations are represented by red lines; positive correlations are denoted by blue lines. ● p < 0.05, adjusted with Benjamini-Hochberg correction.