Figure 2.
Neuroblastoma is populated by immunosuppressive macrophages
(A) UMAP of immune cells.
(B) UMAP and dotplot of myeloid compartment with conventional dendritic cell (cDC), plasmacytoid dendritic cell (pDC), undifferentiated monocyte (Mo), and differentiated macrophage (Mφ) populations showing a selection of their marker genes.
(C) Antigen presenting/co-stimulatory capacity score as constructed with genes in Figure S2F.
(D) M1-like and M2-like macrophage signature score in monocytes and macrophages.28∗∗∗∗p < 0.0001 versus S100hiMo, Kruskal Wallis with Dunn’s.
(E) Flow cytometry of CD163 in myeloid populations. Also see Figure S2.