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Descriptive statistics of mean pevonedistat PK parameters in cycle 1
| Day 1 | Day 5 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cmax (ng/ml) |
T1/2 (hrs) |
CL (L/hr/m2) |
VSS (L/m2) |
AUC0-24h (ng.hr/ml) |
Cmax (ng/ml) |
T1/2 (hrs) |
CL (L/hr/m2) |
VSS (L/m2) |
AUC0-24h (ng.hr/ml) |
|
| Mean | 223 | 4.3 | 23.2 | 104 | 921 | 243 | 4.7 | 20.5 | 96.7 | 1018 |
| Median | 215 | 4.8 | 21.4 | 93.2 | 935 | 213 | 4.7 | 19.1 | 91.0 | 1033 |
| Max | 381 | 5.6 | 40.3 | 190 | 1192 | 400 | 6.1 | 30.7 | 170 | 1381 |
| Min | 121 | 1.8 | 16.2 | 53.8 | 487 | 132 | 1.9 | 14.1 | 56.4 | 638 |
| SD | 90.6 | 1.2 | 6.9 | 41.9 | 215 | 85.4 | 1.1 | 5.4 | 35.6 | 238 |
