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Effect of LT receptor antagonists on the augmentation of phagocytosis in response to exogenous LTB4 and LTC4. AMs were treated with exogenous LTs (LTB4 or LTC4) (1 nM), LTB4 receptor antagonist (LY292476) (1 μM), or cysteinyl-LT receptor antagonist (LY171883) (1 μM) or both before the addition of opsonized K. pneumoniae. Data are expressed as the mean phagocytic index (percentage of control) ± SE (n = 4). ∗, P < 0.05 with respect to the control by ANOVA.
