Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 10;21(2):247–258. doi: 10.1038/s41592-023-02146-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 6 — a, Density plots showing the distribution of peak centers within a 400-nt window in genome flanking the RBFOX2 canonical binding motif ‘UGCAUG’ for RBFOX2 and PTBP1 (negative control) ARTR-seq libraries. b, Density plots showing the distribution of peak centers within a 400-nt window in transcriptome flanking m⁶A sites in HeLa cells identified by m⁶A-SAC-seq³³ for the YTHDF2 ARTR-seq libraries. The distributions in a,b are split into three groups based on the peak signal values. c, Density plots exhibiting the distribution of fragment length for ARTR-seq libraries with or without RNase treatment. d, Density plots showing the distribution of RBFOX2 peak centers within a 400-nt window flanking the RBFOX2 canonical binding motif ‘UGCAUG’ for ARTR-seq libraries without RNase treatment, with weak RNase I treatment and with strong RNase I treatment. The distribution is split into three groups based on the peak signal values. e, qPCR analysis to quantify the relative cDNA yields of ARTR-seq. n = 2 biological replicates. f, Cumulative curves displaying the proportion of the top 3000 RBFOX2 peaks (with the highest signal values) with peak centers located within a certain absolute distance from the nearest ‘UGCAUG’ for ARTR-seq libraries constructed with or without RNase treatment.

Source data