Extended Data Fig. 6. Transcriptional and mutational characterization of clusters demarcated by HOXA-B expression.
a. A heatmap showing expression patterns of HOXA and HOXB cluster genes among molecular categories. Each panel color shows the expression level (log2CPM) of genes. Molecular categories are clustered using the Euclidean distance of the expression levels and the Ward method. b. Expression (left) and ProteinPaint of mutation patterns (right) of FLT3 (top), NRAS (middle), and KRAS (bottom) in the HOXA-B categories. The distribution of log2CPM values among molecular categories is shown for the expression level, and the colors represent molecular categories. For the mutation plots, mutation types and frequencies in the HOXA and HOXB categories are shown separately, and the colors represent mutations types. Statistical significances of mutation distribution and frequency of each mutation were assessed by two-sided Fisher’s exact test (P value), and no adjustment for multiple testing was applied. For each type of NRAS and KRAS mutations, variant allele frequencies (VAFs) are also shown. The lines of the box represent 25% quantile, median, and 75% quantile. The upper whisker represents the higher value of maxima or 1.5 x IQR, and the lower whisker represents the lower value of minima or 1.5 x IQR. Dots represent outliers.