Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jan 11;56(2):281–293. doi: 10.1038/s41588-023-01640-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a, UMAP plot of the entire pAML cohort (n = 887) and cord blood CD34⁺ cells (normal controls: n = 5) using the top 315 variable genes. The colors of each dot denote the molecular categories of the samples. Representative category names are shown, and large clusters enriching specific categories are highlighted in circles (pink: NUP98::NSD1, NPM1, UBTF, DEK::NUP214, KMT2A-PTD; green: KMT2Ar and KAT6Ar; yellow: categories with acute megakaryocytic or erythrocytic expression; blue: MECOM, MNX1, ETS family, PICALM::MLLT10, BCL11B). b, Heatmap showing frequencies of defining gene alterations represented by color. Statistical significance was assessed by two-sided Fisher’s exact test to calculate P values of co-occurrence, followed by Benjamini–Hochberg adjustment for multiple testing to calculate q values (*P < 0.05, **q < 0.05). c, Definition of molecular categories and diagnostic workflow. Molecular categories not defined in WHO^5th are highlighted in red. APL, acute promyelocytic leukemia.

Source data