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. 2024 Feb 13;15:1337. doi: 10.1038/s41467-024-45573-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Cell number (#) or frequency among CD45⁺ cells (%) of CD8⁺ T cells in the PLN and pancreas measured by flow cytometry. Pancreas; 6w (Tyk2^+/−, n = 6; Tyk2^−/−, n = 6), 11w (Tyk2^+/−, n = 5; Tyk2^−/−, n = 9), 14w (Tyk2^+/−, n = 11; Tyk2^−/−, n = 15), and normoglycemic 24w (Tyk2^−/−, n = 8) female NOD mice. PLN; 6w (Tyk2^+/−, n = 9; Tyk2^−/−, n = 7), 11w (Tyk2^+/−, n = 11; Tyk2^−/−, n = 11), 14w (Tyk2^+/−, n = 11; Tyk2^−/−, n = 11), and normoglycemic 24w (Tyk2^−/−, n = 3) female NOD mice. b Frequency of naïve (CD44^lo CD62L⁺), effector memory (CD44^hi CD62L^-), and central memory (CD44^hi CD62L⁺) CD8⁺ T cells in the PLN of 6w female mice (Tyk2^+/−, n = 6; Tyk2^−/−, n = 6). c Frequency of Ki67⁺ cells among the indicated immune cells in the PLN of 6w female mice (Tyk2^+/−, n = 11; Tyk2^−/−, n = 10). d (Left) Representative flow cytometry plots of IFN-γ and IL-17-producing CD8⁺ T cells upon PMA/iono stimulation in the PLN of 6w female mice. (Right) The graphs indicate the frequency of IFN-γ and IL-17-producing CD8⁺ T cells among CD8⁺ T cells in the PLN at the indicated ages (6w (Tyk2^+/−, n = 9; Tyk2^−/−, n = 7), 11w (Tyk2^+/−, n = 9; Tyk2^−/−, n = 10), and 14w (Tyk2^+/−, n = 14; Tyk2^−/−, n = 14)). NT not tested. Data represent the mean ± SEM. P-values were calculated using two-tailed Student’s t tests.