Fig. 2.

Changes in HFMSE score from baseline to 14 (A, D), 26 (B, E), and 38 (C, F) months. Left panels show distribution of changes in HFMSE score from baseline to 14, 26, and 38 months, with each bar representing the proportion of patients who had improved/worsened. The dashed line is the kernel density estimator for the distribution. Box and whisker plots show median (central line), IQR (boxes), and 1.5 × IQR (whiskers), with individual points representing outliers (those outside of 1.5 × IQR from the median). Diamonds indicate mean values. Panels on the right show changes in HFMSE in individual patients from baseline. Each bar represents a single patient. HFMSE = Hammersmith Functional Motor Scale Expanded; IQR = interquartile range.