Fig. 7.

Zbtb16 or Txnip knockdown decreased susceptibility of atrial fibrillation and generation of DADs in db/db mice. A, B Representative DAD images (A, solid arrow) and quantitative analysis (B) of db/ + and db/db mouse atrial myocytes recorded by patch-clamp and analysis of susceptibility (n = 13 for each group). C Representative surface ECGs of ACh-CaCl₂-induced AF model in db/db mice with Zbtb16-KD, Txnip-KD or Mito-TEMPO treatment. Bar = 500 ms. D, E AF incidence (D, n = 12 for each group) and duration (E) analysis. Data in B, D were analyzed by Fisher’s exact test. Data in E were analyzed by two-way ANOVA with Bonferroni’s multiple comparisons test. AF, atrial fibrillation, KD, knockdown