Table 2.
Demographics and clinical characteristics of the included studies.
| Outcomes | Studies | No. of patients | WMD or RR | 95% CI | p-value | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|---|
| Vaccine/Placebo | Chi2 | df | p-value | I2 (%) | |||||
| Age at injection (years) | (1,2,3,5,6) | 7,181/5,431 | 0.06 | [−0.14, 0.25] | 0.57 | 0.46 | 4 | 0.98 | 0 |
| Gestational age at birth | (2,3,5,6) | 3,539/1,755 | −0.02 | [−0.10, 0.07] | 0.70 | 2.48 | 3 | 0.48 | 0 |
| Gestation at injection | (1,3,5) | 7,054/5,335 | 0.00 | [−0.11, 0.11] | 0.98 | 0.02 | 2 | 0.99 | 0 |
| BMI (kg/m2) | (2,5,6) | 3,212/1,677 | 0.07 | [−0.23, 0.37] | 0.67 | 0.39 | 2 | 0.82 | 0 |
| Median Apgar score, 5 min | (1,2,5,6) | 6,738/5,213 | 0.13 | [−0.22, 0.47] | 0.47 | 11,550.07 | 3 | <0.00001 | 100 |
| Length (cm) | (2,5) | 3,148/1,627 | −0.20 | [−0.38, −0.03] | 0.02 | 0.03 | 1 | 0.86 | 0 |
| Weight (kg) | (2,5,6) | 3,170/1,655 | −0.01 | [−0.03,0.02] | 0.73 | 2.54 | 2 | 0.28 | 21 |
| Mode of delivery in study(Vaginal) | (2,3,5,6) | 2,562/1,266 | 1.00 | [0.97, 1.04] | 0.99 | 4.01 | 3 | 0.26 | 25 |
| Infant Sex (male) | (1,2,3,4,5) | 5,151/3,456 | 1.01 | [0.98, 1.04] | 0.44 | 3.63 | 4 | 0.46 | 0 |
BMI, body mass index; WMD, weighted mean difference; RR, relative risk; CI, confidence interval.