Table 2.
Distribution of included SNPs in AD patients and control subjects.
| SNPs | HWE (p value) | Association test | AD | Control | p | OR (95%CI) | p a | OR (95%CI) |
|---|---|---|---|---|---|---|---|---|
| rs1761461 | 0.52 | Genotypic (AA/AC/CC) | 2/41/168 | 4/97/311 | ||||
| Dominant [(AA+AC)/CC] | 43/168 | 101/311 | 0.247 | 0.788 (0.527–1.180) | 0.242 | 0.775 (0.506–1.188) | ||
| Recessive [AA/(AC + CC)] | 2/209 | 4/408 | 0.978 | 0.976 (0.177–5.373) | 0.907 | 0.903 (0.163–5.016) | ||
| Alleles (A/C) | 45/377 | 105/719 | 0.286 | 0.817 (0.564–1.184) | ||||
| rs2452170 | 0.87 | Genotypic (GG/GA/AA) | 204/7/0 | 393/19/0 | ||||
| Dominant [(GG + GA)/AA] | 211/0 | 412/0 | - | - | - | - | ||
| Recessive [GG/(GA + AA)] | 204/7 | 393/19 | 0.445 | 1.409 (0.583–3.407) | 0.621 | 1.269 (0.494–3.257) | ||
| Alleles (G/A) | 415/7 | 805/19 | 0.450 | 1.399 (0.584–3.356) | ||||
| rs5011436 | 0.83 | Genotypic (AA/AC/CC) | 26/97/88 | 41/188/183 | ||||
| Dominant [(AA+AC)/CC] | 123/88 | 229/183 | 0.518 | 1.177 (0.798–1.562) | 0.895 | 1.024 (0.718–1.462)- | ||
| Recessive [AA/(AC + CC)] | 26/185 | 41/371 | 0.366 | 1.272 (0.754–2.144) | 0.318 | 1.327 (0.761–2.314) | ||
| Alleles (A/C) | 149/273 | 270/554 | 0.237 | 1.120 (0.875–1.434) | ||||
| rs6891966 | 0.80 | Genotypic (GG/GA/AA) | 183/28/0 | 357/51/4 | ||||
| Dominant [(GG + GA)/AA] | 211/0 | 408/4 | - | - | - | - | ||
| Recessive [GG/(GA + AA)] | 183/28 | 357/55 | 0.978 | 1.007 (0.618–1.641) | 0.850 | 1.051 (0.629–1.754) | ||
| Alleles (G/A) | 394/28 | 765/59 | 0.731 | 1.085 (0.681–1.729) | ||||
| rs708382 | 0.53 | Genotypic (CC/CT/TT) | 39/109/63 | 72/211/129 | ||||
| Dominant [(CC + CT)/TT] | 148/63 | 283/129 | 0.710 | 1.071 (0.746–1.536) | 0.995 | 1.001 (0.682–1.469)- | ||
| Recessive [CC/(CT + TT)] | 39/172 | 72/340 | 0.756 | 1.071 (0.696–1.647) | 0.867 | 0.962 (0.611–1.513) | ||
| Alleles (C/T) | 187/235 | 355/469 | 0.678 | 1.051 (0.830–1.332) | ||||
| rs871269 | 0.56 | Genotypic (CC/CT/TT) | 43/98/70 | 67/190/155 | ||||
| Dominant [(CC + CT)/TT] | 141/70 | 257/155 | 0.274 | 1.215 (0.857–1.722) | 0.376 | 1.181 (0.817–1.710)- | ||
| Recessive [CC/(CT + TT)] | 43/168 | 67/345 | 0.202 | 1.318 (0.862–2.016) | 0.116 | 1.439 (0.914–2.265) | ||
| Alleles (C/T) | 184/238 | 324/500 | 0.146 | 1.193 (0.941–1.513) | ||||
| rs113020870 | - | Genotypic (CC/CT/TT) | 0/0/211 | 0/0/412 | ||||
| Dominant [(CC + CT)/TT] | 0/211 | 0/412 | - | - | - | - | ||
| Recessive [CC/(CT + TT)] | 0/211 | 0/412 | - | - | - | - | ||
| Alleles (C/T) | 0/422 | 0/824 | - | - | - |
*A two-tailed p < 0.05 was considered significant.
aAdjusted age and sex by logistic regression.
AD, Alzheimer’s disease; SNPs, Single nucleotide polymorphisms; HWE, Hardy–Weinberg equilibrium; CI, Confidence interval; and OR, Odds ratio.