Table 3.
Age-stratified and sex-stratified analysis of 7 loci.
| SNPs | Genotype, allele | Age onset <65 years | Age onset > = 65 years | Male | Female | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AD | Control | p | OR (95%CI) | AD | Control | p | OR (95%CI) | AD | Control | p | OR (95%CI) | AD | Control | p | OR (95%CI) | ||
| rs1761461 | A/A | 2 | 4 | 0.480 | 0 | 0 | 0.816 | 0 | 2 | 0.512 | 2 | 2 | 0.495 | ||||
| A/C | 22 | 75 | 19 | 22 | 16 | 39 | 25 | 58 | |||||||||
| C/C | 93 | 231 | 75 | 80 | 62 | 123 | 106 | 188 | |||||||||
| A | 26 | 83 | 0.374 | 0.809 (0.506–1.292) | 19 | 22 | 0.827 | 0.930 (0.486–1.779) | 16 | 43 | 0.370 | 0.757 (0.412–1.392) | 29 | 62 | 0.517 | 0.857 (0.536–1.368) | |
| C | 208 | 537 | 169 | 182 | 140 | 285 | 237 | 434 | |||||||||
| rs2452170 | G/G | 114 | 295 | 0.297 | 90 | 98 | 0.906 | 77 | 156 | 0.167 | 127 | 237 | 0.973 | ||||
| G/A | 3 | 15 | 4 | 4 | 1 | 8 | 6 | 11 | |||||||||
| A/A | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||
| G | 231 | 605 | 0.302 | 1.909 (0.548–6.656) | 184 | 200 | 0.907 | 0.920 (0.227–3.732) | 155 | 320 | 0.171 | 3.875 (0.480–31.257) | 260 | 485 | 0.973 | 0.983 (0.359–2.688) | |
| A | 3 | 15 | 4 | 4 | 1 | 8 | 6 | 11 | |||||||||
| rs5011436 | A/A | 16 | 31 | 0.516 | 10 | 10 | 0.781 | 11 | 8 | 0.044* | 15 | 33 | 0.807 | ||||
| A/C | 48 | 139 | 49 | 49 | 35 | 79 | 62 | 109 | |||||||||
| C/C | 53 | 140 | 35 | 43 | 32 | 77 | 56 | 106 | |||||||||
| A | 80 | 201 | 0.624 | 1.083 (0.788–1.489) | 69 | 69 | 0.551 | 1.134 (0.749–1.718) | 57 | 95 | 0.093 | 1.142 (0.943–2.115) | 92 | 175 | 0.848 | 0.970 (0.709–1.326) | |
| C | 154 | 419 | 119 | 135 | 99 | 233 | 174 | 321 | |||||||||
| rs6891966 | A/A | 0 | 2 | 0.668 | 0 | 2 | 0.225 | 0 | 1 | 0.782 | 0 | 3 | 0.431 | ||||
| A/G | 15 | 42 | 13 | 9 | 10 | 20 | 18 | 31 | |||||||||
| G/G | 102 | 266 | 81 | 91 | 68 | 143 | 115 | 214 | |||||||||
| A | 15 | 46 | 0.610 | 0.855 (0.468–1.562) | 13 | 13 | 0.829 | 1.091 (0.493–2.418) | 10 | 22 | 0.902 | 0.953 (0.440–2.064) | 18 | 37 | 0.725 | 0.900 (0.502–1.615) | |
| G | 219 | 574 | 175 | 191 | 146 | 306 | 248 | 459 | |||||||||
| rs708382 | C/C | 15 | 54 | 0.507 | 24 | 18 | 0.401 | 19 | 25 | 0.186 | 20 | 47 | 0.448 | ||||
| C/T | 64 | 158 | 45 | 53 | 34 | 87 | 75 | 124 | |||||||||
| T/T | 38 | 98 | 25 | 31 | 25 | 52 | 38 | 77 | |||||||||
| C | 94 | 266 | 0.471 | 0.894 (0.658–1.213) | 93 | 89 | 0.247 | 1.265 (0.850–1.883) | 72 | 137 | 0.363 | 1.195 (0.814–1.754) | 115 | 218 | 0.849 | 0.971 (0.719–1.312) | |
| T | 140 | 354 | 95 | 115 | 84 | 191 | 151 | 278 | |||||||||
| rs871269 | C/C | 22 | 55 | 0.965 | 21 | 12 | 0.093 | 13 | 29 | 0.979 | 30 | 38 | 0.152 | ||||
| C/T | 53 | 141 | 45 | 49 | 35 | 72 | 63 | 118 | |||||||||
| T/T | 42 | 114 | 28 | 41 | 30 | 63 | 40 | 92 | |||||||||
| C | 97 | 251 | 0.797 | 1.041 (0.767–1.413) | 87 | 73 | 0.035* | 1.546 (1.031–2.318) | 61 | 130 | 0.911 | 0.978 (0.662–1.445) | 123 | 194 | 0.057 | 1.339 (0.991–1.809) | |
| T | 137 | 369 | 101 | 131 | 95 | 198 | 143 | 302 | |||||||||
| rs113020870 | C/C | 0 | 0 | - | 0 | 0 | - | 0 | 0 | - | 0 | 0 | - | ||||
| C/T | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||||||
| T/T | 117 | 310 | 94 | 102 | 78 | 164 | 133 | 248 | |||||||||
| C | 0 | 0 | - | - | 0 | 0 | - | - | 0 | 0 | - | - | 0 | 0 | - | - | |
| T | 234 | 620 | 188 | 204 | 156 | 328 | 266 | 496 | |||||||||
*A two-tailed p < 0.05 was considered significant.
AD, Alzheimer’s disease; SNPs, Single nucleotide polymorphisms; HWE, Hardy–Weinberg equilibrium; CI, Confidence interval; and OR, Odds ratio.