Table 4.
Distribution of included SNPs in PD patients and control subjects.
| SNPs | HWE (p value) | Association test | PD | Control | p | OR (95%CI) | p a | OR (95%CI) |
|---|---|---|---|---|---|---|---|---|
| rs1761461 | 0.52 | Genotypic (AA/AC/CC) | 8/99/401 | 4/97/311 | ||||
| Dominant [(AA+AC)/CC] | 107/401 | 101/311 | 0.331 | 0.788 (0.527–1.180) | 0.488 | 0.775 (0.506–1.188) | ||
| Recessive [AA/(AC + CC)] | 8/500 | 4/408 | 0.533 | 0.976 (0.177–5.373) | 0.843 | 0.903 (0.163–5.016) | ||
| Alleles (A/C) | 115/901 | 105/719 | 0.110 | 0.817 (0.564–1.184) | ||||
| rs2452170 | 0.87 | Genotypic (GG/GA/AA) | 496/11/1 | 393/19/0 | ||||
| Dominant [(GG + GA)/AA] | 507/1 | 412/0 | - | - | - | - | ||
| Recessive [GG/(GA + AA)] | 496/12 | 393/19 | 0.149 | 1.409 (0.583–3.407) | 0.366 | 1.269 (0.494–3.257) | ||
| Alleles (G/A) | 1003/13 | 805/19 | 0.213 | 1.399 (0.584–3.356) | ||||
| rs5011436 | 0.83 | Genotypic (AA/AC/CC) | 56/243/208 | 41/188/183 | ||||
| Dominant [(AA+AC)/CC] | 299/208 | 229/183 | 0.196 | 1.177 (0.798–1.562) | 0.395 | 1.024 (0.718–1.462)- | ||
| Recessive [AA/(AC + CC)] | 56/451 | 41/371 | 0.967 | 1.272 (0.754–2.144) | 0.718 | 1.327 (0.761–2.314) | ||
| Alleles (A/C) | 355/659 | 270/554 | 0.330 | 1.120 (0.875–1.434) | ||||
| rs6891966 | 0.80 | Genotypic (GG/GA/AA) | 427/81/0 | 357/51/4 | ||||
| Dominant [(GG + GA)/AA] | 508/0 | 408/4 | - | - | - | - | ||
| Recessive [GG/(GA + AA)] | 427/81 | 357/55 | 0.389 | 1.007 (0.618–1.641) | 0.547 | 1.051 (0.629–1.754) | ||
| Alleles (G/A) | 935/81 | 765/59 | 0.621 | 1.085 (0.681–1.729) | ||||
| rs708382 | 0.53 | Genotypic (CC/CT/TT) | 102/253/153 | 72/211/129 | ||||
| Dominant [(CC + CT)/TT] | 355/153 | 283/129 | 0.919 | 1.071 (0.746–1.536) | 0.736 | 1.001 (0.682–1.469)- | ||
| Recessive [CC/(CT + TT)] | 102/406 | 72/340 | 0.678 | 1.071 (0.696–1.647) | 0.812 | 0.962 (0.611–1.513) | ||
| Alleles (C/T) | 457/559 | 355/469 | 0.415 | 1.051 (0.830–1.332) | ||||
| rs871269 | 0.56 | Genotypic (CC/CT/TT) | 97/266/145 | 67/190/155 | ||||
| Dominant [(CC + CT)/TT] | 363/145 | 257/155 | 0.0035 * | 0 0.741(0.559–0.983) | 0.0047 * | 1.181 (0.817–1.710)- | ||
| Recessive [CC/(CT + TT)] | 97/411 | 67/345 | 0.1093 | 0.918(0.648–1.30) | 0.116 | 1.439 (0.914–2.265) | ||
| Alleles (C/T) | 460/556 | 324/500 | 0.0102 * | 0 0.851(0.703–1.03) | ||||
| rs113020870 | - | Genotypic (CC/CT/TT) | 0/0/508 | 0/0/412 | ||||
| Dominant [(CC + CT)/TT] | 0/508 | 0/412 | - | - | - | - | ||
| Recessive [CC/(CT + TT)] | 0/508 | 0/412 | - | - | - | - | ||
| Alleles (C/T) | 0/1016 | 0/824 | - | - | - |
*A two-tailed p < 0.05 was considered significant.
aAdjusted age and sex by logistic regression.
PD, Parkinson’s disease; SNPs, Single nucleotide polymorphisms; HWE, Hardy–Weinberg equilibrium; CI, Confidence interval; and OR, Odds ratio.