Table 5.
Distribution of included SNPs in PDD patients and PDND patients.
| SNPs | HWE (p value) | Association test | PDD | PDND | p | OR (95%CI) | p a | OR (95%CI) |
|---|---|---|---|---|---|---|---|---|
| rs1761461 | 0.99 | Genotypic (AA/AC/CC) | 1/23/93 | 1/17/88 | ||||
| Dominant [(AA+AC)/CC] | 24/93 | 18/88 | 0.501 | 0.793 (0.403–1.560) | 0.851 | 1.073 (0.513–2.246) | ||
| Recessive [AA/(AC + CC)] | 1/116 | 1/105 | 0.250 | 3.314 (0.382–28.733) | 0.944 | 1.110 (0.060–20.596) | ||
| Alleles (A/C) | 25/209 | 19/193 | 0.944 | 1.105 (0.068–17.885) | ||||
| rs2452170 | 0.99 | Genotypic (GG/GA/AA) | 115/2/0 | 103/3/0 | ||||
| Dominant [(GG + GA)/AA] | 117/0 | 186/0 | - | - | - | - | ||
| Recessive [GG/(GA + AA)] | 115/2 | 103/3 | 0.572 | 0.597 (0.098–3.644) | 0.485 | 1.993 (0.288–13.777) | ||
| Alleles (G/A) | 232/2 | 209/3 | 0.575 | 0.601 (0.099–3.629) | ||||
| rs5011436 | 0.95 | Genotypic (AA/AC/CC) | 14/58/45 | 14/47/45 | ||||
| Dominant [(AA+AC)/CC] | 72/45 | 61/45 | 0.544 | 0.847 (0.496–1.448) | 0.598 | 1.171 (0.651–1.109)- | ||
| Recessive [AA/(AC + CC)] | 14/103 | 14/92 | 0.780 | 1.120 (0.507–2.473) | 0.817 | 1.112 (0.453–2.732) | ||
| Alleles (A/C) | 86/148 | 75/137 | 0.763 | 0.942 (0.640–1.388) | ||||
| rs6891966 | 0.56 | Genotypic (GG/GA/AA) | 100/17/0 | 93/13/0 | ||||
| Dominant [(GG + GA)/AA] | 117/0 | 106/0 | - | - | - | - | ||
| Recessive [GG/(GA + AA)] | 100/17 | 93/13 | 0.620 | 1.216 (0.560–2.641) | 0.456 | 0.720 (0.304–1.707) | ||
| Alleles (G/A) | 217/17 | 199/13 | 0.633 | 1.199 (0.568–2.532) | ||||
| rs708382 | 0.28 | Genotypic (CC/CT/TT) | 31/60/26 | 12/63/31 | ||||
| Dominant [(CC + CT)/TT] | 91/26 | 75/31 | 0.230 | 0.691 (0.378–1.265) | 0.170 | 1.595 (0.818–3.108) | ||
| Recessive [CC/(CT + TT)] | 31/86 | 12/94 | 0.004 * | 0.354 (0.171–0.733) | 0.011 * | 2.801 (1.271–6.173) | ||
| Alleles (C/T) | 122/112 | 87/125 | 0.019 * | 0.639 (0.439–0.930) | ||||
| rs871269 | 0.39 | Genotypic (CC/CT/TT) | 19/63/35 | 14/55/37 | ||||
| Dominant [(CC + CT)/TT] | 82/35 | 69/37 | 0.426 | 0.796 (0.454–1.397) | 0.498 | 1.236 (0.669–2.283) | ||
| Recessive [CC/(CT + TT)] | 19/98 | 14/92 | 0.524 | 0.785 (0.372–1.656) | 0.565 | 1.271 (0.561–2.879) | ||
| Alleles (C/T) | 101/133 | 83/129 | 0.390 | 0.847 (0.580–1.237) | ||||
| rs113020870 | - | Genotypic (CC/CT/TT) | 0/0/117 | 0/0/108 | ||||
| Dominant [(CC + CT)/TT] | 0/117 | 0/108 | - | - | - | - | ||
| Recessive [CC/(CT + TT)] | 0/117 | 0/108 | - | - | - | - | ||
| Alleles (C/T) | 0/234 | 0/216 | - | - | - |
*A two-tailed p < 0.05 was considered significant.
aAdjusted age and sex by logistic regression.
PDD, Parkinson’s disease dementia; PDND, PD without dementia; SNPs, Single nucleotide polymorphisms; HWE, Hardy–Weinberg equilibrium; CI, Confidence interval; and OR, Odds ratio.