Table 2.
Minimum fungicidal concentrations of fluconazole, itraconazole, and curcumin-coated silver nanoparticles against Candida and Aspergillus species
| Fungal species (number of isolates) | Antifungal drugs | MFC range (µg/mL) | GM | Distribution of MICs (µg/mL) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 4 | 8 | 16 | >16 | 32 | 64 | >64 | 128 | 256 | ||||
| Candida albicans (6) | Fluconazole | 1–>64 | 57.01 | 1 | 5 | |||||||||
| Itraconazole | 1–>16 | 8.98 | 1 | 1 | 1 | 3 | ||||||||
| Cur-Ag NPs | 16–32 | 28.51 | 1 | 5 | ||||||||||
| Candida krusei (6) | Fluconazole | >64 | >64 | 6 | ||||||||||
| Itraconazole | 2–>16 | 4.49 | 2 | 3 | 1 | |||||||||
| Cur-Ag NPs | 2–32 | 11.31 | 1 | 1 | 3 | 1 | ||||||||
| Candida parapsilosis (6) | Fluconazole | 2–>64 | 40.32 | 1 | 1 | 4 | ||||||||
| Itraconazole | 1–4 | 2.52 | 1 | 2 | 3 | |||||||||
| Cur-Ag NPs | 8–128 | 22.63 | 3 | 1 | 1 | 1 | ||||||||
| Aspergillus fumigatus (6) | Fluconazole | >64 | >64 | 6 | ||||||||||
| Itraconazole | 4–>16 | 14.25 | 1 | 2 | 3 | |||||||||
| Cur-Ag NPs | 32–128 | 90.51 | 1 | 1 | 4 | |||||||||
| Aspergillus flavus (6) | Fluconazole | >64 | >64 | 6 | ||||||||||
| Itraconazole | 2–16 | 5.04 | 1 | 3 | 1 | 1 | ||||||||
| Cur-Ag NPs | 16–256 | 71.84 | 1 | 1 | 1 | 2 | 1 | |||||||
MFC: minimum fungicidal concentration, MIC: minimum inhibitory concentration, GM: geometric mean, Cur-Ag NPs: curcumin-coated silver nanoparticles