. 2024 Jan 31;26(1):62–69. doi: 10.22074/CELLJ.2023.1995696.1257

Table 2.

The effects of FC and CN on the mitochondria ROS generation, activities of SDH, MDH and LDH in the rat brain homogenate (25 mg/kg, n=5)


Group	ROS	Lipid peroxidation (µM)	SDH activity (U/mg protein/minutes)	MDH activity (U/mg protein/minutes)	LDH activity (U/mg protein/minutes)

Control	106 ± 5^c	3.23 ± 0.56^b	5.48 ± 0.53^a	5.98 ± 0.37^a	5.07 ± 0.54^a
Sham	112 ± 6^c	3.44 ± 0.63^b	5.42 ±0.58^a	5.84 ±0.32^a	4.85 ± 0.51^a
Cerebral IRI	274 ± 18^a	6.23 ±0.78^a	2.88 ± 0.28^b	3.42 ± 0.21^c	3.27 ± 0.25^c
FC	243 ± 16^b	5.78 ± 0.73^a	3.42 ± 0.31^b	3.88 ± 0.34^b	3.58 ± 0.39^b
NC	131 ± 14^c	3.65 ± 0.53^b	5.22 ± 0.43^a	5.42 ± 0.44^a^b	4.86 ± 0.42^a

Data are presented as mean ± SD. Different letters show significant differences, based on the Duncan’s multiple range test, Sham group underwent surgery without BCCAO. FC; Free curcumin at the concentration of 25 mg/kg, CN; Curcumin nanoparticles at the concentration of 25 mg/kg), ROS; Reactive oxygen species, SDH; Succinate dehydrogenase, MDH; Malate dehydrogenase, LDH; Lactate dehydrogenase, BCCAO; Bilateral common carotid artery occlusion, and IRI; Ischemia-reperfusion injury.