. 2024 Jan 29;27(3):108959. doi: 10.1016/j.isci.2024.108959

Table 2.

Differentially abundant metabolites ( $μ$ M) in Brain_NAGLU^−/− compared to WT

Metabolite	p value	q value	Mean of NAGLU^−/−	Mean of WT	Difference	Fold change
Lac	<0.000001	<0.000001	6646	5058	1588	0.12
Ala	<0.000001	<0.000001	343.3	258.5	84.8	0.12
Ser	<0.000001	<0.000001	433.2	336.8	96.33	0.11
Serotonin	<0.000001	<0.000001	2.752	1.389	1.363	0.30
Cit	<0.000001	<0.000001	8.766	5.77	2.996	0.18
Pro	<0.000001	<0.000001	58.24	37.44	20.8	0.19
Lys	<0.000001	<0.000001	97.74	63.06	34.68	0.19
Ile	<0.000001	<0.000001	21.55	15.63	5.918	0.14
Glu	<0.000001	<0.000001	5535	4185	1350	0.12
3-Met-His	<0.000001	<0.000001	0.9482	0.6723	0.2759	0.15
GABA	<0.000001	<0.000001	0.2238	0.4582	−0.2344	−0.31
Suc	<0.000001	<0.000001	308	204.8	103.3	0.18
Orn	<0.000001	<0.000001	4.208	2.61	1.599	0.21
Val	0.000001	0.000005	50.42	38.03	12.38	0.12
HipAcid	0.000001	0.000005	0.1746	0.2685	−0.0939	−0.19
Spermine	0.000007	0.00002	5.956	7.71	−1.754	−0.11
H1	0.000007	0.00002	225.1	168.9	56.17	0.12
Creatinine	0.00003	0.000084	98.01	83.85	14.15	0.07
Gln	0.000034	0.000087	7761	3572	4189	0.34
beta-Ala	0.000088	0.000203	0.947	0.6352	0.3118	0.17
SDMA	0.000115	0.000255	0.0447	0.0288	0.0159	0.19
Choline	0.000128	0.000263	106.2	117.4	−11.18	−0.04
PAG	0.000149	0.000296	0.0214	0.05213	−0.03073	−0.39
Gly	0.000164	0.000314	810.3	682.6	127.7	0.07
Trp	0.000177	0.000328	9.572	6.49	3.082	0.17
Ind-SO4	0.000195	0.000349	7.424	5.941	1.483	0.10
Phe	0.000215	0.000374	40.63	23.8	16.84	0.23
Betaine	0.000238	0.000401	11.53	10.64	0.8827	0.03
Arg	0.000325	0.000531	75.59	72.01	3.577	0.02
CDCA	0.000356	0.000565	0.564	0.3304	0.2336	0.23
Tyr	0.000833	0.00125	38.65	19.58	19.07	0.30
Trigonelline	0.001036	0.001514	0.9762	0.6248	0.3515	0.19
Thr	0.001216	0.001732	133	121.5	11.44	0.04
TMAO	0.001742	0.002419	0.9074	0.553	0.3544	0.22
Sarcosine	0.002007	0.002697	1.446	0.9229	0.5235	0.20
BABA	0.00275	0.003472	0.5718	0.9282	−0.3565	−0.21
AABA	0.003299	0.004072	1.419	1.163	0.2564	0.09
Met-SO	0.007729	0.009334	0.3489	0.1544	0.1945	0.35
Leu	0.008154	0.009638	28.88	21.29	7.599	0.13