TABLE 2.
Isolation of B. burgdorferi from selected tissues and arthritis development in ankles of control and anti-NK1.1 MAb-treated B6C3F1 micea
| Treatment | Day | Culture result (n = 3)
|
Arthritis severity (mean ± SD) | |||||
|---|---|---|---|---|---|---|---|---|
| Blood | Heart | Spleen | Bladder | Ear | Ankle | |||
| Control | 5 | 0 | 0 | 0 | 0 | 0 | 3 | 0.3 ± 0.6 |
| Anti-NK1.1 | 5 | 0 | 0 | 0 | 0 | 0 | 3 | 0.3 ± 0.6 |
| Control | 10 | 1 | 0 | 1 | 3 | 0 | 3 | 2.0 ± 0.8 |
| Anti-NK1.1 | 10 | 0 | 1 | 0 | 3 | 0 | 3 | 1.0 ± 0.0 |
| Control | 15 | 0 | 1 | 1 | 3 | 0 | 3 | 2.0 ± 1.0 |
| Anti-NK1.1 | 15 | 0 | 1 | 1 | 3 | 0 | 3 | 2.0 ± 0.0 |
| Control | 20 | 0 | 2 | 1 | 3 | 3 | 3 | 2.5 ± 0.6 |
| Anti-NK1.1 | 20 | 1 | 1 | 0 | 3 | 3 | 3 | 2.2 ± 0.5 |
| Control | 25 | 0 | 3 | 1 | 3 | 3 | 3 | 3.0 ± 0.0 |
| Anti-NK1.1 | 25 | 0 | 1 | 0 | 3 | 3 | 3 | 2.5 ± 0.6 |
a
Mice were infected with 106 B. burgdorferi spirochetes and sacrificed at 5, 10, 15, 20, and 25 days. Culture results are presented as the number of specimens positive for B. burgdorferi among three tested. Tibiotarsal arthritis development was assessed as for Table 1.